Mesenchymal Stem Cell Based Therapy For Cartilage Repair A Review

Current techniques for cartilage defects repair.

Mesenchymal stem cell based therapy for cartilage repair a review.

In recent years pre clinical experiments and clinical trials have demonstrated that mesenchymal stem cell msc related therapy is a promising option for the treatment of cartilage lesions and oa. Xian 1 2 1 school of pharmacy and medical sciences sansom institute for health research university of south australia city east campus g p o box 2471 adelaide sa 5001 australia. Foster 3 and cory j. Because stem cell therapy for cartilage repair in humans is at an early phase confusion and errors are found in the literature regarding use of the term stem cell therapy in this field.

Mscs isolated from bone marrow bmscs have been widely used in animal models and clinic practice to demonstrate their chondrogenic potential however the incidence of bmsc donors is low. To provide an overview of the outcomes of cartilage repair elucidating the various cell populations used and thus reduce confusion with regard to using the term stem cell therapy. Articular cartilage injury remains one of the major concerns in orthopaedic surgery. Mesenchymal stem cell msc transplantation has been introduced to avoid some of the side effects and complications of current techniques.

A systematic review of. Mesenchymal stem cell based therapy. Filardoinjectable systems for intra articular delivery of mesenchymal stromal cells for cartilage treatment. We explore the challenges associated with cartilage repair and regeneration using cell based therapies that use chondrocytes and mesenchymal stem cells mscs.

A review article literature review pdf available in knee surgery sports traumatology arthroscopy 17 11 1289 97 april 2009 with. Krawetzintra articular injection of synovial mesenchymal stem cells improves cartilage repair in a. Mesenchymal stem cell based therapy for cartilage repair. This review intends to highlight the use of mesenchymal stem cells mscs cell based therapy for articular cartilage repair.

Epub ahead of print human mesenchymal stem cell therapy for cartilage repair. 31 march 2009 springer verlag 2009 abstract articular cartilage injury remains one of the major concerns in orthopaedic surgery. This review article focuses on the structure and function of articular cartilage and the pathogenesis of oa in the context of the rising global burden of musculoskeletal disease. A review hideyuki koga æ lars engebretsen æ jan e.

Thus therapy for replacements of the damaged cartilage is required. Preclinical studies on mesenchymal stem cell based therapy for growth plate cartilage injury repair rosa chung 1 2 bruce k. 4 march 2009 published online.