Mesenchymal Stem Cell Rheumatoid Arthritis

We discuss the use of autologous and allogeneic mesenchymal stem cells in rheumatoid arthritis.

Mesenchymal stem cell rheumatoid arthritis.

Stem cell therapy for rheumatoid arthritis as a chronic autoimmune inflammatory disorder rheumatoid arthritis may be helped with mesenchymal stem cell treatment. Mesenchymal stem cells appear to influence a multitude of inflammatory pathways involved in the pathogenesis of rheumatoid arthritis. The study is a single dose phase i clinical trial and is the first time that this product will be infused in ra patients. 1 george papanicolaou hospital gene and cell therapy center hematology department bmt unit thessaloniki.

Treatment with mesenchymal stem cells mscs has been recently studied in ra due to its immunomodulatory and anti inflammatory capacities. This process is called differentiation. The vast majority of literature pertaining to mesenchymal stem cells msc immunomodulation has focussed on bone marrow derived msc that are systemically infused to alleviate inflammatory conditions. Stem cells have an unprecedented ability to change into any cell in the body.

Thus this study aims at systematically search and review the literature for randomized or non randomized clinical trials comparing interventions of mscs with placebo in ra patients. Mesenchymal stem cells mscs possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune related diseases. Patients were di. This study was designed to assess the safety and efficacy of human umbilical cord mesenchymal stem cells uc mscs in the treatment of rheumatoid arthritis ra.

Bone marrow mesenchymal stem cells bm mscs can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. Papadopoulou a 1 yiangou m athanasiou e zogas n kaloyannidis p batsis i fassas a anagnostopoulos a yannaki e. However it has been well described that peripheral tolerance defects and the. In this ongoing cohort 172 patients with active ra who had inadequate responses to traditional medication were enrolled.

Rheumatoid arthritis ra is the commonest autoimmune joint disease that has witnessed significant therapeutic advances in the past decade but remains stubbornly difficult to treat in a subset of cases. They are expected to be a solution for numerous human conditions. Mesenchymal stem cells are conditionally therapeutic in preclinical models of rheumatoid arthritis. In the last years mesenchymal stem cell msc based therapies have become an interesting therapeutic opportunity for the treatment of rheumatoid arthritis ra due to their capacity to potently modulate the immune response.

This study explored the function of bone marrow mscs from rheumatoid arthritis ra patients focusing on immunomodulatory effects.