Mesenchymal Stem Cell Therapy For Psoriasis

Psoriasis is an incurable immune mediated disease which affects approximately 2 of the world s population.

Mesenchymal stem cell therapy for psoriasis.

Uc mscs umbilical cord derived mesenchymal stem cells. Mesenchymal stem cells to the editor. Background exosomes are nanovesicles secreted from endosomal membranes. 1 here we report 2 cases of psoriasis vulgaris treated by umbilical cord derived mesenchymal stem cells uc mscs.

Mesenchymal stem cells mscs possess unique immunomodulatory properties which make them a promising tool for the treatment of various inflammatory diseases. The anti inflammatory and immunomodulatory properties of mesenchymal stem cells mscs have been proposed to be involved in some autoimmune diseases and have been successfully tested in patients and mice. Our recent preclinical and clinical studies have shown that mscs can be successfully used for the treatment of atopic dermatitis ad one of the major inflammatory skin diseases. Therefore we discovered a novel mechanism of stem cell therapy for psoriasis.

For this reason they are currently under investigation in clinical trials for the treatment of several autoimmune systemic disorders. Current treatments including newly emerged biologic agents have some limitations. A number of studies confirm the involvement of mscs in psoriasis pathogenesis and therefore designate mscs as an important potential therapeutic tool in this setting. Psoriasis is an incurable immune mediated disease which affects approximately 2 of the world s population.

In summary our results showed that msc infusion could be an effective and safe treatment for psoriasis. 3 however recent studies have shown that the prime mover in psoriasis pathogenesis could be linked to a dysfunction in resident mesenchymal stem cells mscs resulting in altered polarization of the immune response. Psoriasis is a systemic immune mediated disease for which mscs could have. A central role is certainly played by t helper th 1 and th17 lymphocytes and by cytokines such as tumour necrosis factor tnf α interleukin il 17 and il 23.

Psoriasis is an incurable immune mediated disease which affects approximately 2 of the world s population. Current treatments including newly emerged biologic agents have some limitations. Mesenchymal stem cells alleviate moderate to severe psoriasis by reducing the production of type i interferon ifn i by plasmacytoid dendritic cells pdcs maosheng chen 1 2 jing peng 2 qi xie 1 2 na xiao 2 xian su 2 hua mei 2 yeping lu 2 jia zhou 2 yanni dai 2 siqi wang 2 chuang li 2 ge lin 1 2 3 and lamei cheng 1 2.