Mesenchymal Stem Cells Knee Osteoarthritis

Many patients with osteoarthritis of the knee fail non operative measures and elect to have knee arthroplasty to improve their quality of life.

Mesenchymal stem cells knee osteoarthritis.

A phase iib randomized placebo controlled clinical trial. The objective of this study is to evaluate the effectiveness safety and potential of mesenchymal stem cells mscs for knee osteoarthritis treatment. Stem cells translational medicine 2019 8 504 511. For knee injections doctors often take stem cells from the patient s bone marrow fat tissue or blood.

Stem cells injection for knee osteoarthritis is still a relatively new treatment and has not yet gained popularity. Lee w s kim hj kim k i et al intra articular injection of autologous adipose tissue derived mesenchymal stem cells for the treatment of knee osteoarthritis. It is characterized by degeneration of articular cartilage and reactive new bone formation at the articular margins causing pain and stiffness of the affected joints the macroscopic features of oa are revealed by radiography and magnetic resonance imaging and the microscopic features by histology. If successful intra articular mesenchymal stem cell msc injections into the knee may offer another viable non operative treatment modality.

A study published in 2017 in the journal of hip preservation surgery showed that injecting autologous cultured mscs from bmc in 10 hip oa patients had all the patients reporting a decrease in pain and increased hip functioning. Bmc mainly contains platelets and mesenchymal stem cells mscs along with other factors. Exp ther med. To evaluate the efficacy of autologous adipose derived mesenchymal stem cell admsc therapy on pain function and disease modification in knee osteoarthritis methods.

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee. This perspective will discuss progress being made with the use of mesenchymal stem cells for the treatment of osteoarthritis oa with particular reference to current studies and the published literature to assess the potential of this emerging area of medicine. Osteoarthritis is a degenerative joint disease characterized by the destruction of joint cartilage. 30 participants with symptomatic knee osteoarthritis were randomized into three groups.

Stem cell therapy is seen as a potential new approach to the treatment of a range of chronic disease states. Two treatment groups received intra articular admsc therapy consisting of either a single injection 100 10 6 admscs or two.